Lanie and her Lost Kids friends continue growing into their semi-pseudo-superhero powers and responsibilities, and learn more about what it means to be a guardian of the odd little town of Neighborlee. Sometimes that meant protecting the rest of the world from the everyday weirdness and magic around them.
The transition from high school to college is marked with challenges and mystical, magical attacks from outside Neighborlee's borders. When the academic game-playing and politics of the local college are used to run a questionable experiment on the entire freshman class, Lanie is there in the middle of it. Sometimes those who realize there's something strange going on aren't as enchanted as Lanie and her geek friends, and it takes a lot of fast talking and faster maneuvering to keep the lid from blowing off the entire town.
The threats grow bigger and the enemies grow meaner, but it's all in a day's work for the guardians of Neighborlee. This is home, and they're willing to pay the price. Sometimes, they do. With their lives.
The really big questions remain: Why are they the way they are and how can they do the things they do? At least when they mess up and use their talents in public, most people don't even notice. It's just part of the background weirdness of Neighborlee, Ohio.